abstract：:Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surface charge and physiological parameters, such as IA injecti...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon R,Wang M,Chaudhuri DB,Ellis JA,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-12-01 00:00:00

abstract：:We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery (SRS)/surgery in brain metastases from patients with non-small cell lung cancer (NSCLC) and clarify the association between treatment outcom...

journal_title：Journal of neuro-oncology

authors： Cai L,Zhu JF,Zhang XW,Lin SX,Su XD,Lin P,Chen K,Zhang LJ

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to test by means of a voxel-based approach the hypothesis that there is a different spatial distribution of brain metastases (BM) and white matter hyperintensities (WMH) and that the presence of WMH affects the location of BM in lung and non-lung cancer patients. Two-hundred consecutive cance...

journal_title：Journal of neuro-oncology

authors： Quattrocchi CC,Errante Y,Mallio CA,Carideo L,Scarciolla L,Santini D,Tonini G,Zobel BB

更新日期：2014-11-01 00:00:00

abstract：:Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma. Many of these tumors are of neuroectodermal or ectomesenchymal origin which is suggestive of TERT promoter mutations playing a role i...

journal_title：Journal of neuro-oncology

authors： Dubbink HJ,Bakels H,Post E,Zwarthoff EC,Verdijk RM

更新日期：2014-11-01 00:00:00

abstract：:Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesio...

journal_title：Journal of neuro-oncology

authors： Boriani S,Lo SF,Puvanesarajah V,Fisher CG,Varga PP,Rhines LD,Germscheid NM,Luzzati A,Chou D,Reynolds JJ,Williams RP,Zadnik P,Groves M,Sciubba DM,Bettegowda C,Gokaslan ZL,AOSpine Knowledge Forum Tumor.

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study is to evaluate prognostic factors of brain metastases from hepatocellular carcinoma. Medical records of 95 patients who have been diagnosed of brain metastases from hepatocellular carcinoma between January 2000 and December 2011 were retrospectively reviewed. The median age at diagnosis of brain ...

journal_title：Journal of neuro-oncology

authors： Kim KS,Kim K,Chie EK,Kim YJ,Yoon JH,Lee HS,Ha SW

更新日期：2014-10-01 00:00:00

abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

journal_title：Journal of neuro-oncology

authors： Vranceanu AM,Merker VL,Plotkin SR,Park ER

更新日期：2014-10-01 00:00:00

abstract：:This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on therapy and outcomes is also examined. All adult patients diagnosed with AA from 2001 to 2011 and treated with st...

journal_title：Journal of neuro-oncology

authors： Kizilbash SH,Giannini C,Voss JS,Decker PA,Jenkins RB,Hardie J,Laack NN,Parney IF,Uhm JH,Buckner JC

更新日期：2014-10-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:Gliomas, the most common malignant primary brain tumors, are universally fatal once they progress from low-grade into high-grade neoplasms. In recent years, we have accumulated unprecedented data about the genetic and epigenetic abnormalities in gliomas; yet, our appreciation of how these deadly tumors arise is still ...

journal_title：Journal of neuro-oncology

authors： Tsankova NM,Canoll P

更新日期：2014-09-01 00:00:00

abstract：:A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

journal_title：Journal of neuro-oncology

authors： Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

更新日期：2014-09-01 00:00:00

abstract：:HDGF is overexpressed in gliomas as compared to normal brain. We therefore analyzed the molecular mechanisms of HDGF action in gliomas. HDGF was downregulated in normal brain tissue as compared to glioma specimens at both the mRNA and the protein levels. In glioma samples, increased HDGF expression was associated with...

journal_title：Journal of neuro-oncology

authors： Song Y,Hu Z,Long H,Peng Y,Zhang X,Que T,Zheng S,Li Z,Wang G,Yi L,Liu Z,Fang W,Qi S

更新日期：2014-09-01 00:00:00

abstract：:Serious dermatologic adverse events such as erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been reported in patients receiving antiepileptic drugs (AEDs) and cranial radiotherapy (RT). Given the frequency of AED-associated rashes and the infrequency of serious dermatolo...

journal_title：Journal of neuro-oncology

authors： Bishop AJ,Chang M,Lacouture ME,Barker CA

更新日期：2014-08-01 00:00:00

abstract：:To test the hypothesis on prolonged survival in glioblastoma cases with increased subventricular zone (SVZ) radiation dose. Sixty glioblastoma cases were previously treated with adjuvant radiotherapy and Temozolamide. Ipsilateral, contralateral and bilateral SVZs were contoured and their doses were retrospectively eva...

journal_title：Journal of neuro-oncology

authors： Elicin O,Inac E,Uzel EK,Karacam S,Uzel OE

更新日期：2014-06-01 00:00:00

abstract：:Primary brain tumors cumulatively represent the most common solid tumors of childhood and are the leading cause of cancer related death in this age group. Traditionally, molecular findings and histological analyses from biopsies of resected tumor tissue have been used for diagnosis and classification of these diseases...

journal_title：Journal of neuro-oncology

authors： Samuel N,Remke M,Rutka JT,Raught B,Malkin D

更新日期：2014-06-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...

journal_title：Journal of neuro-oncology

authors： Anic GM,Madden MH,Nabors LB,Olson JJ,LaRocca RV,Thompson ZJ,Pamnani SJ,Forsyth PA,Thompson RC,Egan KM

更新日期：2014-06-01 00:00:00

abstract：:The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase...

journal_title：Journal of neuro-oncology

authors： Zhao F,Tian J,An L,Yang K

更新日期：2014-06-01 00:00:00

abstract：:Several molecular markers have been proposed as predictors of outcome in patients with high grade gliomas. We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2...

journal_title：Journal of neuro-oncology

authors： Minniti G,Scaringi C,Arcella A,Lanzetta G,Di Stefano D,Scarpino S,Bozzao A,Pace A,Villani V,Salvati M,Esposito V,Giangaspero F,Enrici RM

更新日期：2014-06-01 00:00:00

abstract：:Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chr...

journal_title：Journal of neuro-oncology

authors： Deighton RF,Le Bihan T,Martin SF,Gerth AMJ,McCulloch M,Edgar JM,Kerr LE,Whittle IR,McCulloch J

更新日期：2014-06-01 00:00:00

abstract：:Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80% of cases indicating aggressive treatment modalities, such as gene therapy are warranted. We have examined photochemical intern...

journal_title：Journal of neuro-oncology

authors： Wang F,Zamora G,Sun CH,Trinidad A,Chun C,Kwon YJ,Berg K,Madsen SJ,Hirschberg H

更新日期：2014-05-01 00:00:00

abstract：:Transient cerebral hypoperfusion (TCH) has empirically been used to assist intraarterial (IA) drug delivery to brain tumors. Transient (<3 min) reduction of cerebral blood flow (CBF) occurs during many neuro- and cardiovascular interventions and has recently been used to better target IA drugs to brain tumors. In the ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon RP,Wang M,Chaudhuri DB,Holcomb M,Straubinger NL,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-05-01 00:00:00

abstract：:Bevacizumab has been reported to cause diffusion restriction in the tumor bed of patients with malignant gliomas. This study evaluated prolonged diffusion restriction, in the corpus callosum (CC), of patients with malignant brain tumors treated with bevacizumab. We retrospectively reviewed our database of patients tre...

journal_title：Journal of neuro-oncology

authors： Futterer SF,Nemeth AJ,Grimm SA,Ragin AB,Chandler JP,Muro K,Marymont MH,Raizer JJ

更新日期：2014-05-01 00:00:00

abstract：:Following surgical resection for brain metastases, fractionated stereotactic radiotherapy (FSRT) has been used as an alternative to single dose treatment for large cavities and to reduce risks of late toxicity. The purpose of this study was to evaluate the outcomes of patients treated with FSRT to the post-operative b...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Freilich JM,Abuodeh Y,Figura N,Patel N,Sarangkasiri S,Chinnaiyan P,Yu HH,Etame AB,Rao NG

更新日期：2014-05-01 00:00:00

abstract：:The insular cortex is located deep within the Sylvian fissure between multi-functional and structurally-compressed cerebral structures, and has been suggested to play an important role in both basic sensorimotor and complex social-emotional functions. Such structural and functional complexity presents a challenge for ...

journal_title：Journal of neuro-oncology

authors： Wang X,Gu X,Fan J,Wang S,Zhao F,Hof PR,Liu P,Gao Z

更新日期：2014-04-01 00:00:00

abstract：:Radiation necrosis is a devastating complication following radiation to the central nervous system. The purpose of this study was to perform a comprehensive analysis of cases in the literature using bevacizumab, a monoclonal antibody against vascular endothelial growth factor, as treatment for radiation necrosis. A ME...

journal_title：Journal of neuro-oncology

authors： Tye K,Engelhard HH,Slavin KV,Nicholas MK,Chmura SJ,Kwok Y,Ho DS,Weichselbaum RR,Koshy M

更新日期：2014-04-01 00:00:00

abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...

journal_title：Journal of neuro-oncology

authors： Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

更新日期：2014-04-01 00:00:00

abstract：:Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

journal_title：Journal of neuro-oncology

authors： Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

更新日期：2014-03-01 00:00:00

abstract：:When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...

journal_title：Journal of neuro-oncology

authors： Raizer JJ,Grimm SA,Rademaker A,Chandler JP,Muro K,Helenowski I,Rice L,McCarthy K,Johnston SK,Mrugala MM,Chamberlain M

更新日期：2014-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant glioma. In the current study, 149 astrocytoma gene expression datasets were classified by prediction analysis of microarray. Strikingly, disks large homolog 3 (DLG3), a membrane-associated guanylate kinase-family gene, had the highest score in the GBM subset. DLG3 mR...

journal_title：Journal of neuro-oncology

authors： Liu Z,Niu Y,Xie M,Bu Y,Yao Z,Gao C

更新日期：2014-02-01 00:00:00

abstract：:5-aminolevulinic acid (5-ALA) introduction in the surgical management of Glioblastoma (GBM) enables the intra-operatively identification of cancer cells in the mass by means of fluorescence. Here, we analyzed the phenotype of GBM cells isolated from distinct tumour areas determined by 5-ALA (tumour core, 5-ALA intense...

journal_title：Journal of neuro-oncology

authors： Rampazzo E,Della Puppa A,Frasson C,Battilana G,Bianco S,Scienza R,Basso G,Persano L

更新日期：2014-02-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...

journal_title：Journal of neuro-oncology

authors： Epis MR,Giles KM,Candy PA,Webster RJ,Leedman PJ

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:The pupose of this study is to assess the long-term outcome and toxicity of fractionated stereotactic radiation therapy (FSRT) and stereotactic radiosurgery (SRS) for 100 vestibular schwannomas treated at a single institution. From 1993 to 2007, 104 patients underwent were treated with radiation therapy for ...

journal_title：Journal of neuro-oncology

authors： Anderson BM,Khuntia D,Bentzen SM,Geye HM,Hayes LL,Kuo JS,Baskaya MK,Badie B,Basavatia A,Pyle GM,Tomé WA,Mehta MP

更新日期：2014-01-01 00:00:00

abstract：:Combination of procarbazine, lomustine and vincristine (PCV) with radiation therapy (RT) has been associated with longer survival in patients with anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA), especially in those with chromosome 1p/19q codeletion. We report a multicenter retrospective study ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Arcella A,Scaringi C,Lanzetta G,Di Stefano D,Scarpino S,Pace A,Giangaspero F,Osti MF,Enrici RM

更新日期：2014-01-01 00:00:00

abstract：:To determine the impact of delay between surgery and radiotherapy on overall survival (OS) in temozolomide treatmented patients with the incorporation of O6-methylguanine-DNA methyltransferase (MGMT). From 2000 to 2012, 345 consecutive glioblastoma patients were treated with surgery, radiotherapy, and temozolomide at ...

journal_title：Journal of neuro-oncology

authors： Spratt DE,Folkert M,Zumsteg ZS,Chan TA,Beal K,Gutin PH,Pentsova E,Yamada Y

更新日期：2014-01-01 00:00:00

abstract：:Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to stimulate peripheral blood-derived γδT cells and sensitize tumors to γδT cell-mediated killing. To investigate ...

journal_title：Journal of neuro-oncology

authors： Nakazawa T,Nakamura M,Park YS,Motoyama Y,Hironaka Y,Nishimura F,Nakagawa I,Yamada S,Matsuda R,Tamura K,Sugimoto T,Takeshima Y,Marutani A,Tsujimura T,Ouji N,Ouji Y,Yoshikawa M,Nakase H

更新日期：2014-01-01 00:00:00

abstract：:Temozolomide (TMZ) alone has been proposed as a promising alternative to radiotherapy (RT) in elderly glioblastoma (GBM) patients. We report a meta-analysis to systematically evaluate TMZ monotherapy in older GBM patients. A systematic literature search was performed using PubMed, EMBASE and the Cochrane database. Stu...

journal_title：Journal of neuro-oncology

authors： Yin AA,Cai S,Dong Y,Zhang LH,Liu BL,Cheng JX,Zhang X

更新日期：2014-01-01 00:00:00

abstract：:Although stereotactic radiosurgery (SRS) is an effective treatment option for patients with brain tumors, its increased use has raised concern for increased incidence of radiation necrosis (RN). No established standard or guidelines exists regarding non-invasive techniques to diagnose or treat RN. This study was condu...

journal_title：Journal of neuro-oncology

authors： Stockham AL,Ahluwalia M,Reddy CA,Suh JH,Kumar A,Vogelbaum MA,Barnett GH,Murphy ES,Chao ST

更新日期：2013-12-01 00:00:00

abstract：:Primary intramedullary spinal cord tumors are a rare entity, comprising 4–10 %of all spinal cord tumors. The current report presents data on intramedullary spinal cord anaplastic astrocytomas and glioblastomas in adults using the national surveillance, epidemiology, and end results database (1973–2008), and evaluates ...

journal_title：Journal of neuro-oncology

authors： Wong AP,Dahdaleh NS,Fessler RG,Melkonian SC,Lin Y,Smith ZA,Lam SK

更新日期：2013-12-01 00:00:00

abstract：:This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...

journal_title：Journal of neuro-oncology

authors： Lubelski D,Abdullah KG,Weil RJ,Marko NF

更新日期：2013-12-01 00:00:00